Month: December 2021

Weight loss once was considered a simple calculation: eat less and move more to create a calorie deficit. Now, basic differences between people — in genetics, health conditions, body type, and more — are also thought to play a role in how challenging it is to lose weight. Yet research suggests that some factors may help set the stage for success.

Sleep more to eat less? New research boosts this premise, suggesting that adults who are better rested consume significantly fewer calories than those who are chronically sleep-deprived.

This short-term study of 80 overweight people drives home just how integral slumber — or lack of it — is to our propensity to put on excess pounds, says Dr. Beth Frates, director of lifestyle medicine and wellness in the department of surgery at Massachusetts General Hospital.

“Working to find ways to clean up sleep hygiene may help people to extend sleep time to the recommended seven to nine hours per night,” Dr. Frates says. “This could, in turn, lead to consuming fewer calories and even weight loss in people who are in the overweight category by BMI.”

Sleep shortfall linked to chronic diseases

The new study, published in JAMA Internal Medicine, reinforces earlier findings indicating that people who sleep less consume more calories — and even crave higher-calorie foods — compared with those who sleep for longer periods.

About one-third of Americans don’t sleep the recommended seven to nine hours each night, Dr. Frates notes, and this shortfall is linked to many chronic diseases, including high blood pressure, heart disease, diabetes, and obesity. Sleep, she says, is one of the six pillars of lifestyle medicine — a list that also includes exercise, nutritious eating, stress reduction, social connection, and avoiding risky substances.

“Most people focus on exercise and diet when it comes to weight management and a healthy heart, but few focus on sleep,” she says.

Tracking sleep cycles, calories, and weight

The study participants were adults ages 21 to 40 with a BMI between 25.0 and 29.9, which is considered overweight. All of them routinely slept less than 6.5 hours each night. For the first two weeks, all maintained normal sleep patterns.

For the second two weeks, participants were randomly split into two equal groups. With the aim of lengthening sleep times to 8.5 hours, one group received individualized counseling pointing out ways to alter sleep-busting factors relating to bed partner, children, and pets.

“The advice wasn’t generalized,” Dr. Frates notes. “It was specific to the person, and then there was a follow-up visit with more counseling.” The second group of participants continued their typical sleep habits.

All were told to keep up daily routines without changing diet or exercise habits. Each wore a wrist device that tracked their sleep cycles, and they weighed themselves each morning. Sophisticated lab tests teased out the difference between the number of calories each participant consumed and expended each day.

Balancing appetite-regulating hormones

Researchers found participants who received sleep hygiene counseling slept for more than an hour longer each night than those continuing their prior sleep habits. Extended-sleep participants also consumed an average of 270 fewer calories each day and lost about a pound compared to control group participants, who gained just under a pound on average.

The findings are exciting, because they reveal the power of education and counseling on behavior change — in this case sleep, Dr. Frates says. Significant extra slumber time can help people feel like they’re thriving rather than just surviving, she adds.

But why might extra sleep matter? Sleep duration has long been linked to the body’s production of appetite-regulating hormones. Insufficient sleep is associated with higher levels of the hormone ghrelin, which increases appetite, and lower levels of the hormone leptin, which leads to feeling less full. This sets people up to gain weight. By contrast, sleeping more could alter these hormones and bring them back to balance.

“People might also feel more alert, energized, and happier with more sleep,” Dr. Frates adds. “This could lead to more activity, even if it isn’t exercise. It may lead to less sitting and more socializing.”

It’s worth noting that the study didn’t reveal whether the extended sleep pattern was maintained after the two-week intervention period, or what types of food participants ate and when.

The study had other limitations, too. “Were the people in the sleep extension intervention making healthier choices?” Dr. Frates asks. “Calories are important, but what makes up those calories is equally important. Measuring hunger levels, cravings, and stress levels would also provide important information.”

Takeaway tactics to improve your sleep

A few key tactics from the study could help you improve how long you sleep — and possibly help you take in fewer calories:

• Keep a sleep log
• Monitor sleep times with wrist actigraphy devices such as smartwatches
• Evaluate bedtime routines to tweak factors influencing sleep duration
• Limit use of electronic devices at least an hour before bed.

About the Author

Maureen Salamon, Executive Editor, Harvard Women’s Health Watch

Maureen Salamon is executive editor of Harvard Women’s Health Watch. She began her career as a newspaper reporter and later covered health and medicine for a wide variety of websites, magazines, and hospitals. Her work has appeared in The New York Times, The Atlantic, CNN.com, WebMD, Medscape and HealthDay, among other major outlets. Maureen earned a BA in print journalism from Penn State University. View all posts by Maureen Salamon

You were recently started on antibiotics for an infection and you are now doing well. But slowly your skin begins to itch, and the telltale signs of a rash are already popping up — first on your torso, and now spreading to your arms and legs. What do you do? Should you worry? Should you see a medical professional?

Rashes are a common and pesky side effect of many medications. It can be so disheartening to be getting better from one ailment only to discover that you have another issue to address. While these itchy eruptions can be annoying, they usually run their course over a week or two and can be treated with topical medications.

But not all drug rashes are created equal — and some can even be deadly. Luckily the scary ones are pretty rare, but it’s still a good idea to know how to spot them. How can you tell the serious rashes from ones that are just a nuisance, but will get better with time and treatment?

Types of drug rashes

There are two main allergic rashes that may happen after taking a drug. The most immediate type of reaction happens within hours. Hives appear and move around the skin. Since this process is related to the release of histamine, antihistamines (available over the counter at a drugstore) are the typical treatment.

There is also a delayed type of drug rash that comes up four to 14 days after you start taking a medication. Pink and red bumps appear on your chest and back, and spread to the arms and legs over the course of days. Unlike hives, these bumps don’t move around, and after a few days things may start to get better, but you may have peeling skin much like a healing sunburn.

This delayed type of rash doesn’t respond as well to antihistamines, but an over-the-counter topical cortisone cream (or one of its stronger prescription-strength versions) can help speed the healing process along.

When is a drug rash cause for concern and a visit to the ER?

With hives, the main concern is that you’re experiencing a whole-body reaction that goes beyond the skin, one that can make breathing difficult or dangerously drops your blood pressure. If you experience either of these symptoms, it’s very important to get to the ED.

These immediate, life-threatening reactions can be treated with steroids, epinephrine, and higher-dose antihistamines than you can find at the drug store. While they are scary, these types of allergic reactions to a drug are not hard to identify, and many doctors are skilled at spotting dramatic changes in your breathing or blood pressure. It’s important to tell the doctor you see what medications you have taken and how long ago you took them.

Know the signs of severe cutaneous adverse reactions (SCARs)

In the more delayed type of rash, symptoms can be more difficult to diagnose. The most common triggers for these types of rashes include antibiotics, antiseizure medications, antigout medications like allopurinol, and even over-the-counter medications like NSAIDs. (This isn’t a complete list, and any new medication should be regarded with caution.)

As for the rash, when it’s just itching things are usually fine, but still a nuisance. When the skin starts to hurt, or turns a deeper purple color, doctors worry about something more serious. If your skin starts to blister up or you see pustules, or if you notice sores in your mouth, eyes, or your genitalia, these are red flags and you should get to an urgent care clinic or the ER and ask for a dermatology consultation. Sores in the mouth can be so severe that drooling becomes a common symptom, because patients avoid swallowing due to the pain.

If you start to feel ill, like you have the flu, or if you’re getting puffy from swelling, especially in the face, this could mean it’s a severe drug hypersensitivity syndrome. Sometimes people develop a fever, a drop in their blood pressure, or their liver, kidneys, and heart can all be affected by drug hypersensitivity syndromes. These are so severe that most patients need to be admitted to the hospital, and sometimes even to the burn or intensive care unit.

While there are different names for different types of severe drug reactions, including Stevens-Johnson syndrome (SJS), drug rash with eosinophilia and systemic symptoms (DRESS), and acute generalized exanthematous pustulosis (AGEP), they are often grouped together as severe cutaneous adverse reactions (SCARs).

What happens if you develop a SCAR from a medication?

The first step is getting evaluated by a specialist, either in a dermatological clinic or the hospital. Finding someone who has expertise in managing these types of reactions is critical. A doctor (usually a dermatologist) may biopsy your skin, and they may have to start systemic medications that suppress your immune system. Sometimes, patients with SCARs also require a stay in a hospital.

The most important thing you can do is to keep an eye on your skin and its symptoms if you’re taking a new medication, or even if you’ve increased the dose of an old medication. If you suspect that you may be dealing with one of these SCARs, be sure to seek help from an expert, like a board-certified dermatologist, so that you can rest assured that you’re getting the care you need. Patients who are treated appropriately generally do well. Your doctors should also report these reactions to the FDA.

Once you’re on the mend, things can start to get back to normal, but it’s important to follow up with your doctors because there are some long-term issues that are important to pay attention to. Ultimately your doctors and healthcare team will advise you on what exactly is safe in the future. Remember that if you’re worried about one of these reactions, it’s important to stop the medication as soon as possible, but with the input of your doctors.

About the Author

Stephen Chen, MD, MPH, Contributor

Dr. Steven Chen is a board-certified internist and dermatologist. He is an assistant professor at Harvard Medical School. Dr. Chen earned his MD and an MPH from Johns Hopkins University. He then pursued residency training at Harvard, where he completed an internal medicine residency at Beth Israel Deaconess Medical Center, and a dermatology residency in the Harvard dermatology program. Dr. Chen attends on both the dermatology and internal medicine services with a clinical and research interest in oncodermatology. He co-directs the comprehensive cutaneous lymphoma program at Massachusetts General Hospital, and serves as an associate program director for the Harvard dermatology residency program. View all posts by Stephen Chen, MD, MPH